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CAN008

CAN008


CAN008 is a glycosylation fusion protein that blocks the interaction between the CD95 receptor and its cognate ligand CD95L through binding to the CD95 ligand (CD95L). It has a unique dual mechanism of action, which can inhibit the invasive growth of tumor cells and the programmed cell death of T cells, and repair immune function. 


CAN008 is among the first batch of biopharmaceutical products in China to enter the Marketing Authorization Holder (MAH). Three early phase clinical studies have been conducted in Europe to assess the PK, safety and efficacy of CAN008. A phase I study in Asian patients was completed as well. The good safety and primary efficacy of CAN008 have been proven.


Indication:Glioblastoma


Glioblastoma (GBM) is a Class IV glioma classified by the World Health Organization. It is the most common primary intracranial tumor with the most invasive and highly malignant nature. GBM can express CD95L, which is a key triggering factor for invasion and migration of GBM cells. Neutralization of CD95L can inhibit the migration and infiltration of glioblastoma cells, reduce the apoptosis of T cells induced by CD95L and enhance the immunity against GBM.